Research Papers: Imaging

Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array

[+] Author Affiliations
Guo Li, Lei Li, Liren Zhu, Jun Xia, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, One Brookings Drive, St. Louis, Missouri 63130, United States

J. Biomed. Opt. 20(6), 066010 (Jun 25, 2015). doi:10.1117/1.JBO.20.6.066010
History: Received April 8, 2015; Accepted May 29, 2015
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Abstract.  Due to their low cost, hand-held convenience, wide selection of bandwidths, and ultrasound imaging capability, linear ultrasonic transducer arrays have been widely studied for photoacoustic computed tomography (PACT). As linear-array PACT suffers from a limited view, full-view imaging requires either the transducer or the object to be rotated. So far, both the central frequencies and bandwidth of linear transducer arrays applied in full-view PACT are low, limiting the spatial resolutions of the reconstructed images. Here, we present a multiview high-frequency PACT imaging system implemented with a commercial 40-MHz central frequency linear transducer array. By rotating the object through multiple angles with respect to the linear transducer array, we acquired full-view photoacoustic pressure measurements. Further, to quantify the unipolar initial pressures and overcome the limitations of the single-view Hilbert transformation, we developed a multiview Hilbert transformation method. The in-plane spatial resolution of this full-view linear-array PACT was quantified to be isotropically 60μm within a 10×10mm2 field of view. The system was demonstrated by imaging both a leaf skeleton and a zebrafish in vivo.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Guo Li ; Lei Li ; Liren Zhu ; Jun Xia and Lihong V. Wang
"Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array", J. Biomed. Opt. 20(6), 066010 (Jun 25, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.6.066010


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