JBO Letters

Excitation-resolved cone-beam x-ray luminescence tomography

[+] Author Affiliations
Xin Liu, Zhuangzhi Yan

Shanghai University, School of Communication and Information Engineering, Shanghai 200444, China

Qimei Liao

Fourth Military Medical University, Department of Biomedical Engineering, Xi’an 710032, China

Hongkai Wang

Dalian University of Technology, Department of Biomedical Engineering, Dalian 116024, China

J. Biomed. Opt. 20(7), 070501 (Jul 09, 2015). doi:10.1117/1.JBO.20.7.070501
History: Received April 26, 2015; Accepted June 9, 2015
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Abstract.  Cone-beam x-ray luminescence computed tomography (CB-XLCT), as an emerging imaging technique, plays an important role in in vivo small animal imaging studies. However, CB-XLCT suffers from low-spatial resolution due to the ill-posed nature of reconstruction. We improve the imaging performance of CB-XLCT by using a multiband excitation-resolved imaging scheme combined with principal component analysis. To evaluate the performance of the proposed method, the physical phantom experiment is performed with a custom-made XLCT/XCT imaging system. The experimental results validate the feasibility of the method, where two adjacent nanophosphors (with an edge-to-edge distance of 2.4 mm) can be located.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Xin Liu ; Qimei Liao ; Hongkai Wang and Zhuangzhi Yan
"Excitation-resolved cone-beam x-ray luminescence tomography", J. Biomed. Opt. 20(7), 070501 (Jul 09, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.7.070501


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