Research Papers: Imaging

In vivo microvascular network imaging of the human retina combined with an automatic three-dimensional segmentation method

[+] Author Affiliations
Shenghai Huang

Wenzhou Medical University, School of Optometry and Ophthalmology, 270 Xueyuan Road, Wenzhou 325027, China

University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612, United States

Zhonglie Piao, Jiang Zhu

University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612, United States

Fan Lu

Wenzhou Medical University, School of Optometry and Ophthalmology, 270 Xueyuan Road, Wenzhou 325027, China

Zhongping Chen

Wenzhou Medical University, School of Optometry and Ophthalmology, 270 Xueyuan Road, Wenzhou 325027, China

University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612, United States

University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697, United States

J. Biomed. Opt. 20(7), 076003 (Jul 13, 2015). doi:10.1117/1.JBO.20.7.076003
History: Received March 17, 2015; Accepted June 12, 2015
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Abstract.  Microvascular network of the retina plays an important role in diagnosis and monitoring of various retinal diseases. We propose a three-dimensional (3-D) segmentation method with intensity-based Doppler variance (IBDV) based on swept-source optical coherence tomography. The automatic 3-D segmentation method is used to obtain seven surfaces of intraretinal layers. The microvascular network of the retina, which is acquired by the IBDV method, can be divided into six layers. The microvascular network of the six individual layers is visualized, and the morphology and contrast images can be improved by using the segmentation method. This method has potential for earlier diagnosis and precise monitoring in retinal vascular diseases.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Shenghai Huang ; Zhonglie Piao ; Jiang Zhu ; Fan Lu and Zhongping Chen
"In vivo microvascular network imaging of the human retina combined with an automatic three-dimensional segmentation method", J. Biomed. Opt. 20(7), 076003 (Jul 13, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.7.076003


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