Research Papers: Imaging

Optically-tracked handheld fluorescence imaging platform for monitoring skin response in the management of soft tissue sarcoma

[+] Author Affiliations
Emilie Chamma, Liis Lindvere-Teene, Kristina M. Blackmore, Safa Majeed

University Health Network, Princess Margaret Cancer Centre, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Toronto, Ontario M5G 1L7, Canada

Jimmy Qiu

Princess Margaret Cancer Centre, Radiation Medicine Program, 610 University Avenue, Toronto M5G 2M9, Canada

Robert Weersink

University Health Network, Princess Margaret Cancer Centre, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Toronto, Ontario M5G 1L7, Canada

Princess Margaret Cancer Centre, Radiation Medicine Program, 610 University Avenue, Toronto M5G 2M9, Canada

University Health Network, Techna Institute, 124-100 College Street, Toronto, Ontario M5G 1P5, Canada

Colleen I. Dickie

Princess Margaret Cancer Centre, Radiation Medicine Program, 610 University Avenue, Toronto M5G 2M9, Canada

Princess Margaret Cancer Centre, Department of Radiation Oncology, 610 University Avenue, Toronto M5G 2M9, Canada

Anthony M. Griffin

Division of Orthopedic Surgery, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Canada

Jay S. Wunder, Peter C. Ferguson

Division of Orthopedic Surgery, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Canada

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Canada

Ralph S. DaCosta

University Health Network, Princess Margaret Cancer Centre, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Toronto, Ontario M5G 1L7, Canada

University Health Network, Techna Institute, 124-100 College Street, Toronto, Ontario M5G 1P5, Canada

University of Toronto, Department of Medical Biophysics, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Room 15-701, Toronto, Ontario M5G 1L7, Canada

J. Biomed. Opt. 20(7), 076011 (Jul 27, 2015). doi:10.1117/1.JBO.20.7.076011
History: Received January 25, 2015; Accepted June 25, 2015
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Abstract.  Standard clinical management of extremity soft tissue sarcomas includes surgery with radiation therapy. Wound complications (WCs) arising from treatment may occur due to bacterial infection and tissue breakdown. The ability to detect changes in these parameters during treatment may lead to earlier interventions that mitigate WCs. We describe the use of a new system composed of an autofluorescence imaging device and an optical three-dimensional tracking system to detect and coregister the presence of bacteria with radiation doses. The imaging device visualized erythema using white light and detected bacterial autofluorescence using 405-nm excitation light. Its position was tracked relative to the patient using IR reflective spheres and registration to the computed tomography coordinates. Image coregistration software was developed to spatially overlay radiation treatment plans and dose distributions on the white light and autofluorescence images of the surgical site. We describe the technology, its use in the operating room, and standard operating procedures, as well as demonstrate technical feasibility and safety intraoperatively. This new clinical tool may help identify patients at greater risk of developing WCs and investigate correlations between radiation dose, skin response, and changes in bacterial load as biomarkers associated with WCs.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Emilie Chamma ; Jimmy Qiu ; Liis Lindvere-Teene ; Kristina M. Blackmore ; Safa Majeed, et al.
"Optically-tracked handheld fluorescence imaging platform for monitoring skin response in the management of soft tissue sarcoma", J. Biomed. Opt. 20(7), 076011 (Jul 27, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.7.076011


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