Research Papers: Imaging

Development of ultraviolet- and visible-light one-shot spectral domain optical coherence tomography and in situ measurements of human skin

[+] Author Affiliations
Heijiro Hirayama, Sohichiro Nakamura

Analysis Technology Center, R&D Management Headquarters, Fujifilm Co., 210 Nakanuma, Minami-Ashigara-shi, Kanagawa 250-0193, Japan

J. Biomed. Opt. 20(7), 076014 (Jul 29, 2015). doi:10.1117/1.JBO.20.7.076014
History: Received March 13, 2015; Accepted June 12, 2015
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Abstract.  We have developed ultraviolet (UV)- and visible-light one-shot spectral domain (SD) optical coherence tomography (OCT) that enables in situ imaging of human skin with an arbitrary wavelength in the UV–visible-light region (370–800 nm). We alleviated the computational burden for each color OCT image by physically dispersing the irradiating light with a color filter. The system consists of SD-OCT with multicylindrical lenses; thus, mechanical scanning of the mirror or stage is unnecessary to obtain an OCT image. Therefore, only a few dozens of milliseconds are necessary to obtain single-image data. We acquired OCT images of one subject’s skin in vivo and of a skin excision ex vivo for red (R, 650±20nm), green (G, 550±20nm), blue (B, 450±20nm), and UV (397±5nm) light. In the visible-light spectrum, R light penetrated the skin and was reflected at a lower depth than G or B light. On the skin excision, we demonstrated that UV light reached the dermal layer. We anticipated that basic knowledge about the spectral properties of human skin in the depth direction could be acquired with this system.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Heijiro Hirayama and Sohichiro Nakamura
"Development of ultraviolet- and visible-light one-shot spectral domain optical coherence tomography and in situ measurements of human skin", J. Biomed. Opt. 20(7), 076014 (Jul 29, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.7.076014


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