Spatiotemporal correlation of optical coherence tomography in-vivo images of rabbit airway for the diagnosis of edema

DongYel Kang; Alex Wang; Veronika Volgger; Zhongping Chen; Brian J. F. Wong

doi:10.1117/1.JBO.20.7.076015

29 July 2015 Spatiotemporal correlation of optical coherence tomography in-vivo images of rabbit airway for the diagnosis of edema

DongYel Kang, Alex Wang, Veronika Volgger, Zhongping Chen, Brian J. F. Wong

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Journal of Biomedical Optics, Vol. 20, Issue 7, 076015 (July 2015). https://doi.org/10.1117/1.JBO.20.7.076015

Abstract

Detection of an early stage of subglottic edema is vital for airway management and prevention of stenosis, a life-threatening condition in critically ill neonates. As an observer for the task of diagnosing edema in vivo, we investigated spatiotemporal correlation (STC) of full-range optical coherence tomography (OCT) images acquired in the rabbit airway with experimentally simulated edema. Operating the STC observer on OCT images generates STC coefficients as test statistics for the statistical decision task. Resulting from this, the receiver operating characteristic (ROC) curves for the diagnosis of airway edema with full-range OCT in-vivo images were extracted and areas under ROC curves were calculated. These statistically quantified results demonstrated the potential clinical feasibility of the STC method as a means to identify early airway edema.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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DongYel Kang, Alex Wang, Veronika Volgger, Zhongping Chen, and Brian J. F. Wong "Spatiotemporal correlation of optical coherence tomography in-vivo images of rabbit airway for the diagnosis of edema," Journal of Biomedical Optics 20(7), 076015 (29 July 2015). https://doi.org/10.1117/1.JBO.20.7.076015

Published: 29 July 2015

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