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11 August 2015 Noncontact diffuse correlation tomography of human breast tumor
Lian He, Yu Lin, Chong Huang, Daniel Irwin, Margaret M. Szabunio, Guoqiang Yu
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Journal of Biomedical Optics, Vol. 20, Issue 8, 086003 (August 2015). https://doi.org/10.1117/1.JBO.20.8.086003
Abstract
Our first step to adapt our recently developed noncontact diffuse correlation tomography (ncDCT) system for three-dimensional (3-D) imaging of blood flow distribution in human breast tumors is reported. A commercial 3-D camera was used to obtain breast surface geometry, which was then converted to a solid volume mesh. An ncDCT probe scanned over a region of interest on the mesh surface and the measured boundary data were combined with a finite element framework for 3-D image reconstruction of blood flow distribution. This technique was tested in computer simulations and in vivo human breasts with low-grade carcinoma. Results from computer simulations suggest that relatively high accuracy can be achieved when the entire tumor is within the sensitive region of diffuse light. Image reconstruction with a priori knowledge of the tumor volume and location can significantly improve the accuracy in recovery of tumor blood flow contrasts. In vivo imaging results from two breast carcinomas show higher average blood flow contrasts (5.9- and 10.9-fold) in the tumor regions compared to the surrounding tissues, which are comparable with previous findings using diffuse correlation spectroscopy. The ncDCT system has the potential to image blood flow distributions in soft and vulnerable tissues without distorting tissue hemodynamics.
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Lian He, Yu Lin, Chong Huang, Daniel Irwin, Margaret M. Szabunio, and Guoqiang Yu "Noncontact diffuse correlation tomography of human breast tumor," Journal of Biomedical Optics 20(8), 086003 (11 August 2015). https://doi.org/10.1117/1.JBO.20.8.086003
Published: 11 August 2015
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KEYWORDS
Tumors
Breast
Tissues
Blood circulation
Image restoration
Tomography
Ultrasonography
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