Research Papers: Sensing

In vivo photoacoustic flowmetry at depths of the diffusive regime based on saline injection

[+] Author Affiliations
Yong Zhou, Joemini Poudel, Guo Li, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, 1 Brookings Drive, Campus Box 1097, St. Louis, Missouri 63130, United States

J. Biomed. Opt. 20(8), 087001 (Aug 12, 2015). doi:10.1117/1.JBO.20.8.087001
History: Received May 18, 2015; Accepted July 20, 2015
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Abstract.  We propose a saline injection-based method to quantify blood flow velocity in vivo with acoustic-resolution photoacoustic tomography. By monitoring the saline–blood interface propagating in the blood vessel, the flow velocity can be resolved. We first demonstrated our method in phantom experiments, where a root mean square error of prediction of 0.29mm/s was achieved. By injecting saline into a mouse tail vein covered with 1 mm chicken tissue, we showed that the flow velocity in the tail vein could be measured at depths, which is especially pertinent to monitoring blood flow velocity in patients undergoing intravenous infusion.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Yong Zhou ; Joemini Poudel ; Guo Li and Lihong V. Wang
"In vivo photoacoustic flowmetry at depths of the diffusive regime based on saline injection", J. Biomed. Opt. 20(8), 087001 (Aug 12, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.8.087001


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