Research Papers: Imaging

Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method

[+] Author Affiliations
Haixiao Liu, Xin Yang, Liangliang Shi, Zhenhua Hu, Kun Wang, Jie Tian

Chinese Academy of Sciences, Key Laboratory of Molecular Imaging, Institute of Automation, Zhongguancun East Road No. 95, Beijing 100190, China

Beijing Key Laboratory of Molecular Imaging, Zhongguancun East Road No. 95, Beijing 100190, China

Tianming Song, Chengpeng Bao

Chinese Academy of Sciences, Key Laboratory of Molecular Imaging, Institute of Automation, Zhongguancun East Road No. 95, Beijing 100190, China

J. Biomed. Opt. 20(8), 086007 (Aug 13, 2015). doi:10.1117/1.JBO.20.8.086007
History: Received March 16, 2015; Accepted July 15, 2015
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Abstract.  Cerenkov luminescence tomography (CLT) is a promising tool that enables three-dimensional noninvasive in vivo detection of radiopharmaceuticals. Conventionally, multispectral information and diffusion theory were introduced to achieve whole-body tomographic reconstruction. However, the diffusion theory inevitably causes systematic error in blue bands of the electromagnetic spectrum due to high-tissue absorption, and CL has a blue-weighted broad spectrum. Therefore, it is challenging to improve the accuracy of CLT. The performance of the n-order simplified spherical harmonics approximation (SPn) in different spectra is evaluated, and a multispectral hybrid CLT based on the combination of different SPn models is proposed to handle the Cerenkov photon transport problem in complex media. The in vivo xenograft experiment shows that this approach can effectively improve the quality and accuracy of the reconstructed light source. We believe that the new reconstruction method will advance the development of CLT for more in vivo imaging applications.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Haixiao Liu ; Xin Yang ; Tianming Song ; Chengpeng Bao ; Liangliang Shi, et al.
"Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method", J. Biomed. Opt. 20(8), 086007 (Aug 13, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.8.086007


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