Research Papers: Imaging

Increasing depth penetration in biological tissue imaging using 808-nm excited Nd3+/Yb3+/Er3+-doped upconverting nanoparticles

[+] Author Affiliations
Hugo Söderlund, Monirehalsadat Mousavi, Haichun Liu, Stefan Andersson-Engels

Lund University, Biophotonics Group, Department of Physics, P.O. Box 118, SE-22100 Lund, Sweden

J. Biomed. Opt. 20(8), 086008 (Aug 13, 2015). doi:10.1117/1.JBO.20.8.086008
History: Received March 23, 2015; Accepted July 15, 2015
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Abstract.  Ytterbium (Yb3+)-sensitized upconverting nanoparticles (UCNPs) are excited at 975 nm causing relatively high absorption in tissue. A new type of UCNPs with neodymium (Nd3+) and Yb3+ codoping is excitable at a 808-nm wavelength. At this wavelength, the tissue absorption is lower. Here we quantify, both experimentally and theoretically, to what extent Nd3+-doped UCNPs will provide an increased signal at larger depths in tissue compared to conventional 975-nm excited UCNPs.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Hugo Söderlund ; Monirehalsadat Mousavi ; Haichun Liu and Stefan Andersson-Engels
"Increasing depth penetration in biological tissue imaging using 808-nm excited Nd3+/Yb3+/Er3+-doped upconverting nanoparticles", J. Biomed. Opt. 20(8), 086008 (Aug 13, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.8.086008


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