Research Papers: Imaging

Functional response of cerebral blood flow induced by somatosensory stimulation in rats with subarachnoid hemorrhage

[+] Author Affiliations
Zhiguo Li

Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, China

Qin Huang, Pengcheng Li, Jinling Lu

Huazhong University of Science and Technology, Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, 1037 Luo yu Road, Wuhan 430074, China

Peng Liu

Wuhan General Hospital of Guangzhou Military Command, Department of Neurosurgery, 627 Wuluo Road, Wuhan 430070, China

Lianting Ma

Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, China

Wuhan General Hospital of Guangzhou Military Command, Department of Neurosurgery, 627 Wuluo Road, Wuhan 430070, China

J. Biomed. Opt. 20(9), 096008 (Sep 10, 2015). doi:10.1117/1.JBO.20.9.096008
History: Received December 25, 2014; Accepted August 3, 2015
Text Size: A A A

Abstract.  Subarachnoid hemorrhage (SAH) is often accompanied by cerebral vasospasm (CVS), which is the phenomenon of narrowing of large cerebral arteries, and then can produce delayed ischemic neurological deficit (DIND) such as lateralized sensory dysfunction. CVS was regarded as a major contributor to DIND in patients with SAH. However, therapy for preventing vasospasm after SAH to improve the outcomes may not work all the time. It is important to find answers to the relationship between CVS and DIND after SAH. How local cerebral blood flow (CBF) is regulated during functional activation after SAH still remains poorly understood, whereas, the regulation of CBF may play an important role in weakening the impact of CVS on cortex function. Therefore, it is worthwhile to evaluate the functional response of CBF in the activated cortex in an SAH animal model. Most evaluation of the effect of SAH is presently carried out by neurological behavioral scales. The functional imaging of cortical activation during sensory stimulation may help to reflect the function of the somatosensory cortex more locally than the behavioral scales do. We investigated the functional response of CBF in the somatosensory cortex induced by an electrical stimulation to contralateral forepaw via laser speckle imaging in a rat SAH model. Nineteen Sprague-Dawley rats from two groups (control group, n=10 and SAH group, n=9) were studied. SAH was induced in rats by double injection of autologous blood into the cisterna magna after CSF aspiration. The same surgical procedure was applied in the control group without CSF aspiration or blood injection. Significant CVS was found in the SAH group. Meanwhile, we observed a delayed peak of CBF response in rats with SAH compared with those in the control group, whereas no significant difference was found in magnitude, duration, and areas under curve of relative CBF changes between the two groups. The results suggest that the regulation function of local CBF during functional activation induced by somatosensory stimulation might not be seriously impaired in the somatosensory cortex of rats with SAH. Therefore, our findings might help to understand the clinical phenomenon that DIND might not occur even when CVS was found in SAH patients.

Figures in this Article
© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Zhiguo Li ; Qin Huang ; Peng Liu ; Pengcheng Li ; Lianting Ma, et al.
"Functional response of cerebral blood flow induced by somatosensory stimulation in rats with subarachnoid hemorrhage", J. Biomed. Opt. 20(9), 096008 (Sep 10, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.9.096008


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.