Research Papers: General

Efficacy and predictability of soft tissue ablation using a prototype Raman-shifted alexandrite laser

[+] Author Affiliations
John A. Kozub, M. Shane Hutson

Vanderbilt University, Department of Physics and Astronomy, 6301 Stevenson Center, Nashville, Tennessee 37235, United States

Jin-H. Shen, Karen M. Joos, Ratna Prasad

Vanderbilt University Medical Center, Department of Ophthalmology and Vanderbilt Eye Institute, 2311 Pierce Avenue, Nashville, Tennessee 37232, United States

J. Biomed. Opt. 20(10), 105004 (Oct 12, 2015). doi:10.1117/1.JBO.20.10.105004
History: Received May 28, 2015; Accepted August 28, 2015
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Abstract.  Previous research showed that mid-infrared free-electron lasers could reproducibly ablate soft tissue with little collateral damage. The potential for surgical applications motivated searches for alternative tabletop lasers providing thermally confined pulses in the 6- to-7-μm wavelength range with sufficient pulse energy, stability, and reliability. Here, we evaluate a prototype Raman-shifted alexandrite laser. We measure ablation thresholds, etch rates, and collateral damage in gelatin and cornea as a function of laser wavelength (6.09, 6.27, or 6.43μm), pulse energy (up to 3mJ/pulse), and spot diameter (100 to 600μm). We find modest wavelength dependence for ablation thresholds and collateral damage, with the lowest thresholds and least damage for 6.09μm. We find a strong spot-size dependence for all metrics. When the beam is tightly focused (100-μm diameter), ablation requires more energy, is highly variable and less efficient, and can yield large zones of mechanical damage (for pulse energies >1mJ). When the beam is softly focused (300-μm diameter), ablation proceeded at surgically relevant etch rates, with reasonable reproducibility (5% to 12% within a single sample), and little collateral damage. With improvements in pulse-energy stability, this prototype laser may have significant potential for soft-tissue surgical applications.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

John A. Kozub ; Jin-H. Shen ; Karen M. Joos ; Ratna Prasad and M. Shane Hutson
"Efficacy and predictability of soft tissue ablation using a prototype Raman-shifted alexandrite laser", J. Biomed. Opt. 20(10), 105004 (Oct 12, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.10.105004


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