Special Section on Optical Medical Imaging Standards

Double-integrating-sphere system at the National Institute of Standards and Technology in support of measurement standards for the determination of optical properties of tissue-mimicking phantoms

[+] Author Affiliations
Paul Lemaillet, David W. Allen

National Institute of Standards and Technology, Physical Measurement Laboratory, 100 Bureau Drive, Gaithersburg, Maryland 20899, United States

Jean-Pierre Bouchard

Institut National d’Optique, 2740 Einstein Street, Québec G1P 4S4, Canada

Jeeseong Hwang

National Institute of Standards and Technology, Physical Measurement Laboratory, 325 Broadway Street, Boulder, Colorado 80305, United States

J. Biomed. Opt. 20(12), 121310 (Oct 27, 2015). doi:10.1117/1.JBO.20.12.121310
History: Received May 8, 2015; Accepted September 29, 2015
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Abstract.  There is a need for a common reference point that will allow for the comparison of the optical properties of tissue-mimicking phantoms. After a brief review of the methods that have been used to measure the phantoms for a contextual backdrop to our approach, this paper reports on the establishment of a standardized double-integrating-sphere platform to measure absorption and reduced scattering coefficients of tissue-mimicking biomedical phantoms. The platform implements a user-friendly graphical user interface in which variations of experimental configurations and model-based analysis are implemented to compute the coefficients based on a modified inverse adding-doubling algorithm allowing a complete uncertainty evaluation. Repeatability and validation of the measurement results of solid phantoms are demonstrated for three samples of different thicknesses, d=5.08mm, 7.09 mm, and 9.92 mm, with an absolute error estimate of 4.0% to 5.0% for the absorption coefficient and 11% to 12% for the reduced scattering coefficient (k=2). The results are in accordance with those provided by the manufacturer. Measurements with different polarization angles of the incident light are also presented, and the resulting optical properties were determined to be equivalent within the estimated uncertainties.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Paul Lemaillet ; Jean-Pierre Bouchard ; Jeeseong Hwang and David W. Allen
"Double-integrating-sphere system at the National Institute of Standards and Technology in support of measurement standards for the determination of optical properties of tissue-mimicking phantoms", J. Biomed. Opt. 20(12), 121310 (Oct 27, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.12.121310


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