Research Papers: Imaging

Monitoring photodynamic therapy with photoacoustic microscopy

[+] Author Affiliations
Peng Shao, Roger J. Zemp

University of Alberta, Department of Electrical & Computer Engineering, 9107-116 Street, Edmonton T6G 2V4, Canada

David W. Chapman, Ronald B. Moore

University of Alberta, Department of Surgery and Oncology, 11560 University Avenue, Edmonton T6G 1Z2, Canada

J. Biomed. Opt. 20(10), 106012 (Oct 28, 2015). doi:10.1117/1.JBO.20.10.106012
History: Received June 2, 2015; Accepted October 1, 2015
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Abstract.  We present our work on examining the feasibility of monitoring photodynamic therapy (PDT)-induced vasculature change with acoustic-resolution photoacoustic microscopy (PAM). Verteporfin, an FDA-approved photosensitizer for clinical PDT, was utilized. With a 60-μm-resolution PAM system, we demonstrated the capability of PAM to monitor PDT-induced vasculature variations in a chick chorioallantoic membrane model with topical application and in a rat ear with intravenous injection of the photosensitizer. We also showed oxygen saturation change in target blood vessels due to PDT. Success of the present approach may potentially lead to the application of PAM imaging in evaluating PDT efficacy, guiding treatment, and predicting responders from nonresponders.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Peng Shao ; David W. Chapman ; Ronald B. Moore and Roger J. Zemp
"Monitoring photodynamic therapy with photoacoustic microscopy", J. Biomed. Opt. 20(10), 106012 (Oct 28, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.10.106012


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