Research Papers: General

Holographic analysis on deformation and restoration of malaria-infected red blood cells by antimalarial drug

[+] Author Affiliations
Hyeokjun Byeon

Pohang University of Science and Technology, Department of Mechanical Engineering, San 31. Hyoja-dong, Namgu, Pohang 790-784, Republic of Korea

Young-Ran Ha

Pohang University of Science and Technology, Division of Integrative Biosciences and Biotech, San 31. Hyoja-dong, Namgu, Pohang 790-784, Republic of Korea

Sang Joon Lee

Pohang University of Science and Technology, Department of Mechanical Engineering, San 31. Hyoja-dong, Namgu, Pohang 790-784, Republic of Korea

Pohang University of Science and Technology, Division of Integrative Biosciences and Biotech, San 31. Hyoja-dong, Namgu, Pohang 790-784, Republic of Korea

J. Biomed. Opt. 20(11), 115003 (Nov 06, 2015). doi:10.1117/1.JBO.20.11.115003
History: Received September 4, 2015; Accepted October 15, 2015
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Abstract.  Malaria parasites induce morphological, biochemical, and mechanical changes in red blood cells (RBCs). Mechanical variations are closely related to the deformability of individual RBCs. The deformation of various RBCs, including healthy and malaria-infected RBCs (iRBCs), can be directly observed through quantitative phase imaging (QPI). The effects of chloroquine treatment on the mechanical property variation of iRBCs were investigated using time-resolved holographic QPI of single live cells on a millisecond time scale. The deformabilities of healthy RBCs, iRBCs, and drug-treated iRBCs were compared, and the effect of chloroquine on iRBC restoration was experimentally examined. The present results are beneficial to elucidate the dynamic characteristics of iRBCs and the effect of the antimalarial drug on iRBCs.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Hyeokjun Byeon ; Young-Ran Ha and Sang Joon Lee
"Holographic analysis on deformation and restoration of malaria-infected red blood cells by antimalarial drug", J. Biomed. Opt. 20(11), 115003 (Nov 06, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.11.115003


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