Research Papers: General

Vibrational mapping of sinonasal lesions by Fourier transform infrared imaging spectroscopy

[+] Author Affiliations
Elisabetta Giorgini

Università Politecnica delle Marche, Dipartimento di Scienze della Vita e dell’Ambiente, Via Brecce Bianche, 60131 Ancona, Italy

Simona Sabbatini, Carla Conti

Università Politecnica delle Marche, Dipartimento di Scienze e Ingegneria della Materia, dell’Ambiente ed Urbanistica, Via Brecce Bianche, 60131 Ancona, Italy

Corrado Rubini

Università Politecnica delle Marche, Dipartimento di Scienze Biomediche e Sanità Pubblica, Via Conca, 71, 60126 Torrette (Ancona), Italy

Romina Rocchetti

Università Politecnica delle Marche, Dipartimento di Scienze della Vita e dell’Ambiente, Via Brecce Bianche, 60131 Ancona, Italy

Università Politecnica delle Marche, Dipartimento di Scienze Biomediche e Sanità Pubblica, Via Conca, 71, 60126 Torrette (Ancona), Italy

Massimo Re

Università Politecnica delle Marche, Dipartimento di Malattie Immuno-Allergiche e Respiratorie, Via Conca, 71, 60126 Torrette (Ancona), Italy

Lisa Vaccari, Elisa Mitri

Elettra—Sincrotrone Trieste, S.S. 14, Km 163.5, 34012 Basovizza (Trieste), Italy

Vito Librando

Università degli Studi di Catania, Dipartimento di Scienze Chimiche, Via Andrea Doria, 6, 580138 Catania, Italy

J. Biomed. Opt. 20(12), 125003 (Dec 16, 2015). doi:10.1117/1.JBO.20.12.125003
History: Received July 8, 2015; Accepted November 11, 2015
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Abstract.  Fourier transform infrared imaging (FTIRI) is a powerful tool for analyzing biochemical changes in tumoral tissues. The head and neck region is characterized by a great variety of lesions, with different degrees of malignancy, which are often difficult to diagnose. Schneiderian papillomas are sinonasal benign neoplasms arising from the Schneiderian mucosa; they can evolve into malignant tumoral lesions (squamous cell carcinoma). In addition, they can sometimes be confused with the more common inflammatory polyps. Therefore, an early and definitive diagnosis of this pathology is mandatory. Progressing in our research on the study of oral cavity lesions, 15 sections consisting of inflammatory sinonasal polyps, benign Schneiderian papillomas, and sinonasal undifferentiated carcinomas were analyzed using FTIRI. To allow a rigorous description of these pathologies and to gain objective diagnosis, the epithelial layer and the adjacent connective tissue of each section were separately investigated by following a multivariate analysis approach. According to the nature of the lesion, interesting modifications were detected in the average spectra of the different tissue components, above all in the lipid and protein patterns. Specific band-area ratios acting as spectral markers of the different pathologies were also highlighted.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Elisabetta Giorgini ; Simona Sabbatini ; Carla Conti ; Corrado Rubini ; Romina Rocchetti, et al.
"Vibrational mapping of sinonasal lesions by Fourier transform infrared imaging spectroscopy", J. Biomed. Opt. 20(12), 125003 (Dec 16, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.12.125003


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