Research Papers: Imaging

Tri-band spectroscopic optical coherence tomography based on optical parametric amplification for lipid and vessel visualization

[+] Author Affiliations
Luoqin Yu, Jiqiang Kang, Chandra Jinata, Xie Wang, Xiaoming Wei, Kenneth K. Y. Wong

The University of Hong Kong, Photonic Systems Research Laboratory, Department of Electrical and Electronic Engineering, Pokfulam Road, Hong Kong, China

Kin Tak Chan, Nikki P. Lee

The University of Hong Kong, Department of Surgery, Hong Kong, Pokfulam Road, Hong Kong, China

J. Biomed. Opt. 20(12), 126006 (Dec 16, 2015). doi:10.1117/1.JBO.20.12.126006
History: Received August 10, 2015; Accepted November 12, 2015
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Abstract.  A tri-band spectroscopic optical coherence tomography (SOCT) system has been implemented for visualization of lipid and blood vessel distribution. The tri-band swept source, which covers output spectrum in 1.3, 1.5, and 1.6μm wavelength windows, is based on a dual-band Fourier domain mode-locked laser and a fiber optical parametric amplifier. This tri-band SOCT can further differentiate materials, e.g., lipid and artery, qualitatively by contrasting attenuation coefficients difference within any two of these bands. Furthermore, ex vivo imaging of both porcine artery with artificial lipid plaque phantom and mice with coronary artery disease were demonstrated to showcase the capability of our SOCT.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Luoqin Yu ; Jiqiang Kang ; Chandra Jinata ; Xie Wang ; Xiaoming Wei, et al.
"Tri-band spectroscopic optical coherence tomography based on optical parametric amplification for lipid and vessel visualization", J. Biomed. Opt. 20(12), 126006 (Dec 16, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.12.126006


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