Special Section on Selected Topics in Biophotonics: Photoacoustic Tomography and Fiber-Based Lasers and Supercontinuum Sources

In vivo photoacoustic tomography of myoglobin oxygen saturation

[+] Author Affiliations
Li Lin, Junjie Yao, Lei Li, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, St. Louis, Missouri 63130, United States

J. Biomed. Opt. 21(6), 061002 (Dec 17, 2015). doi:10.1117/1.JBO.21.6.061002
History: Received June 16, 2015; Accepted September 11, 2015
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Abstract.  Myoglobin is an essential oxygen-binding hemoprotein in skeletal and cardiac muscles that buffers intracellular oxygen (O2) concentration in response to hypoxia or elevated muscle activities. We present a method that uses photoacoustic computed tomography to measure the distribution of myoglobin in tissue and the oxygen saturation of myoglobin (sO2-Mb). From photoacoustic measurements of mice in different oxygenation states, we performed calibration-free quantification of the sO2-Mb change in the backbone muscle in vivo.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Li Lin ; Junjie Yao ; Lei Li and Lihong V. Wang
"In vivo photoacoustic tomography of myoglobin oxygen saturation", J. Biomed. Opt. 21(6), 061002 (Dec 17, 2015). ; http://dx.doi.org/10.1117/1.JBO.21.6.061002


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