Research Papers: Imaging

Photoacoustic tomography of vascular compliance in humans

[+] Author Affiliations
Pengfei Hai, Yong Zhou, Jinyang Liang, Chiye Li, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, One Brookings Drive, St. Louis, Missouri 63130, United States

J. Biomed. Opt. 20(12), 126008 (Dec 21, 2015). doi:10.1117/1.JBO.20.12.126008
History: Received September 11, 2015; Accepted November 19, 2015
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Abstract.  Characterization of blood vessel elastic properties can help in detecting thrombosis and preventing life-threatening conditions such as acute myocardial infarction or stroke. Vascular elastic photoacoustic tomography (VE-PAT) is proposed to measure blood vessel compliance in humans. Implemented on a linear-array-based photoacoustic computed tomography system, VE-PAT can quantify blood vessel compliance changes due to simulated thrombosis and occlusion. The feasibility of the VE-PAT system was first demonstrated by measuring the strains under uniaxial loading in perfused blood vessel phantoms and quantifying their compliance changes due to the simulated thrombosis. The VE-PAT system detected a decrease in the compliances of blood vessel phantoms with simulated thrombosis, which was validated by a standard compression test. The VE-PAT system was then applied to assess blood vessel compliance in a human subject. Experimental results showed a decrease in compliance when an occlusion occurred downstream from the measurement point in the blood vessels, demonstrating VE-PAT’s potential for clinical thrombosis detection.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Pengfei Hai ; Yong Zhou ; Jinyang Liang ; Chiye Li and Lihong V. Wang
"Photoacoustic tomography of vascular compliance in humans", J. Biomed. Opt. 20(12), 126008 (Dec 21, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.12.126008


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