Research Papers: Imaging

Visualizing biofilm formation in endotracheal tubes using endoscopic three-dimensional optical coherence tomography

[+] Author Affiliations
Andrew E. Heidari, Zhongping Chen

University of California Irvine, Samueli School of Engineering, Department of Biomedical Engineering, 5200 Engineering Hall, Irvine, California 92697-2700, United States

Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92617, United States

Samer Moghaddam, Kimberly K. Truong

University of California Irvine, UC Irvine Health, Pulmonology, 101, The City Drive South, Orange, California 92868, United States

Lidek Chou

Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92617, United States

Carl Genberg

N8 Medical, 7165 Mira Monte Circle, Las Vegas, Nevada 89120, United States

Matthew Brenner

Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92617, United States

University of California Irvine, UC Irvine Health, Pulmonology, 101, The City Drive South, Orange, California 92868, United States

J. Biomed. Opt. 20(12), 126010 (Dec 22, 2015). doi:10.1117/1.JBO.20.12.126010
History: Received May 26, 2015; Accepted November 23, 2015
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Abstract.  Biofilm formation has been linked to ventilator-associated pneumonia, which is a prevalent infection in hospital intensive care units. Currently, there is no rapid diagnostic tool to assess the degree of biofilm formation or cellular biofilm composition. Optical coherence tomography (OCT) is a minimally invasive, nonionizing imaging modality that can be used to provide high-resolution cross-sectional images. Biofilm deposited in critical care patients’ endotracheal tubes was analyzed in vitro. This study demonstrates that OCT could potentially be used as a diagnostic tool to analyze and assess the degree of biofilm formation and extent of airway obstruction caused by biofilm in endotracheal tubes.

Figures in this Article
© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Andrew E. Heidari ; Samer Moghaddam ; Kimberly K. Truong ; Lidek Chou ; Carl Genberg, et al.
"Visualizing biofilm formation in endotracheal tubes using endoscopic three-dimensional optical coherence tomography", J. Biomed. Opt. 20(12), 126010 (Dec 22, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.12.126010


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