Research Papers: General

Calibration of diffuse correlation spectroscopy blood flow index with venous-occlusion diffuse optical spectroscopy in skeletal muscle

[+] Author Affiliations
Zhe Li

University of Pennsylvania, Department of Physics & Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, United States

Tianjin University, School of Precision Instrument and Opto-Electronics Engineering, Tianjin 300072, China

Tianjin University, State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin 300072, China

Wesley B. Baker, Ashwin B. Parthasarathy, Steven Schenkel, Arjun G. Yodh

University of Pennsylvania, Department of Physics & Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, United States

Tiffany S. Ko

University of Pennsylvania, Department of Bioengineering, 210 South 33rd Street, Philadelphia, Pennsylvania 19104, United States

Detian Wang

University of Pennsylvania, Department of Physics & Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, United States

Institute of Fluid Physics, Mianyang 621000, China

Turgut Durduran

ICFO-Institut de Ciéncies Fotóniques, Mediterranean Technology Park, 08860 Castelldefels (Barcelona), Spain

Gang Li

Tianjin University, School of Precision Instrument and Opto-Electronics Engineering, Tianjin 300072, China

Tianjin University, State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin 300072, China

J. Biomed. Opt. 20(12), 125005 (Dec 23, 2015). doi:10.1117/1.JBO.20.12.125005
History: Received August 24, 2015; Accepted November 17, 2015
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Abstract.  We investigate and assess the utility of a simple scheme for continuous absolute blood flow monitoring based on diffuse correlation spectroscopy (DCS). The scheme calibrates DCS using venous-occlusion diffuse optical spectroscopy (VO-DOS) measurements of arm muscle tissue at a single time-point. A calibration coefficient (γ) for the arm is determined, permitting conversion of DCS blood flow indices to absolute blood flow units, and a study of healthy adults (N=10) is carried out to ascertain the variability of γ. The average DCS calibration coefficient for the right (i.e., dominant) arm was γ=(1.24±0.15)×108(mL·100mL1·min1)/(cm2/s). However, variability can be significant and is apparent in our site-to-site and day-to-day repeated measurements. The peak hyperemic blood flow overshoot relative to baseline resting flow was also studied following arm-cuff ischemia; excellent agreement between VO-DOS and DCS was found (R2=0.95, slope=0.94±0.07, mean difference=0.10±0.45). Finally, we show that incorporation of subject-specific absolute optical properties significantly improves blood flow calibration accuracy.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Zhe Li ; Wesley B. Baker ; Ashwin B. Parthasarathy ; Tiffany S. Ko ; Detian Wang, et al.
"Calibration of diffuse correlation spectroscopy blood flow index with venous-occlusion diffuse optical spectroscopy in skeletal muscle", J. Biomed. Opt. 20(12), 125005 (Dec 23, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.12.125005


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