Research Papers: General

Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during plantar flexion exercise

[+] Author Affiliations
Brad Henry, Mingjun Zhao, Yu Shang, Guoqiang Yu

University of Kentucky, College of Engineering, Department of Biomedical Engineering, 143 Graham Avenue, Lexington, Kentucky 40506-0108, United States

Timothy Uhl

University of Kentucky, College of Health Sciences, Department of Rehabilitation Science, 900 S Limestone Street, Lexington, Kentucky 40536-0200, United States

D. Travis Thomas

University of Kentucky, College of Health Sciences, Department of Clinical Sciences, 900 S Limestone Street, Lexington, Kentucky 40536-0200, United States

Eleftherios S. Xenos, Sibu P. Saha

University of Kentucky, College of Medicine, Department of Surgery, 900 S Limestone Street, Lexington, Kentucky 40536-0200, United States

J. Biomed. Opt. 20(12), 125006 (Dec 23, 2015). doi:10.1117/1.JBO.20.12.125006
History: Received July 15, 2015; Accepted November 20, 2015
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Abstract.  Occlusion calibrations and gating techniques have been recently applied by our laboratory for continuous and absolute diffuse optical measurements of forearm muscle hemodynamics during handgrip exercises. The translation of these techniques from the forearm to the lower limb is the goal of this study as various diseases preferentially affect muscles in the lower extremity. This study adapted a hybrid near-infrared spectroscopy and diffuse correlation spectroscopy system with a gating algorithm to continuously quantify hemodynamic responses of medial gastrocnemius during plantar flexion exercises in 10 healthy subjects. The outcomes from optical measurement include oxy-, deoxy-, and total hemoglobin concentrations, blood oxygen saturation, and relative changes in blood flow (rBF) and oxygen consumption rate (rV˙O2). We calibrated rBF and rV˙O2 profiles with absolute baseline values of BF and V˙O2 obtained by venous and arterial occlusions, respectively. Results from this investigation were comparable to values from similar studies. Additionally, significant correlation was observed between resting local muscle BF measured by the optical technique and whole limb BF measured concurrently by a strain gauge venous plethysmography. The extensive hemodynamic and metabolic profiles during exercise will allow for future comparison studies to investigate the diagnostic value of hybrid technologies in muscles affected by disease.

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© 2015 Society of Photo-Optical Instrumentation Engineers

Citation

Brad Henry ; Mingjun Zhao ; Yu Shang ; Timothy Uhl ; D. Travis Thomas, et al.
"Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during plantar flexion exercise", J. Biomed. Opt. 20(12), 125006 (Dec 23, 2015). ; http://dx.doi.org/10.1117/1.JBO.20.12.125006


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