Research Papers: Imaging

In vivo use of hyperspectral imaging to develop a noncontact endoscopic diagnosis support system for malignant colorectal tumors

[+] Author Affiliations
Zhimin Han

Peking University, College of Engineering, Department of Biomedical Engineering, Liaokaiyuan Building, Room 2-301, Haidian, Beijing 100871, China

Georgia Institute of Technology and Emory University, The Wallace H. Coulter Department of Biomedical Engineering, 313 Ferst Drive, Room 4106, Atlanta, Georgia 30332, United States

Aoyu Zhang, Xiguang Wang, Zongxiao Sun, Tianyu Xie

Peking University, College of Engineering, Department of Biomedical Engineering, Liaokaiyuan Building, Room 2-301, Haidian, Beijing 100871, China

May D. Wang

Georgia Institute of Technology and Emory University, The Wallace H. Coulter Department of Biomedical Engineering, 313 Ferst Drive, Room 4106, Atlanta, Georgia 30332, United States

J. Biomed. Opt. 21(1), 016001 (Jan 06, 2016). doi:10.1117/1.JBO.21.1.016001
History: Received October 24, 2015; Accepted December 2, 2015
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Abstract.  The early detection and diagnosis of malignant colorectal tumors enables the initiation of early-stage therapy and can significantly increase the survival rate and post-treatment quality of life among cancer patients. Hyperspectral imaging (HSI) is recognized as a powerful tool for noninvasive cancer detection. In the gastrointestinal field, most of the studies on HSI have involved ex vivo biopsies or resected tissues. In the present study, we aimed to assess the difference in the in vivo spectral reflectance of malignant colorectal tumors and normal mucosa. A total of 21 colorectal tumors or adenomatous polyps from 12 patients at Shanghai Zhongshan Hospital were examined using a flexible hyperspectral (HS) colonoscopy system that can obtain in vivo HS images of the colorectal mucosa. We determined the optimal wavelengths for differentiating tumors from normal tissue based on these recorded images. The application of the determined wavelengths in spectral imaging in clinical trials indicated that such a clinical support system comprising a flexible HS colonoscopy unit and band selection unit is useful for outlining the tumor region and enhancing the display of the mucosa microvascular pattern in vivo.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Zhimin Han ; Aoyu Zhang ; Xiguang Wang ; Zongxiao Sun ; May D. Wang, et al.
"In vivo use of hyperspectral imaging to develop a noncontact endoscopic diagnosis support system for malignant colorectal tumors", J. Biomed. Opt. 21(1), 016001 (Jan 06, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.1.016001


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