Research Papers: Therapeutic

Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection

[+] Author Affiliations
Zhuo Chen, Mingdong Huang

Chinese Academy of Sciences, Fujian Institute of Research on the Structure of Matter, State Key Laboratory of Structural Chemistry, 155 West Yangqiao Road, Fuzhou, Fujian 350002, China

Graduate University of Chinese Academy of Sciences, 19 Yuquan Road, Shijingshan District, Beijing 100049, China

Yaxin Zhang, Dong Wang

Chinese Academy of Sciences, Fujian Institute of Research on the Structure of Matter, State Key Laboratory of Structural Chemistry, 155 West Yangqiao Road, Fuzhou, Fujian 350002, China

Graduate University of Chinese Academy of Sciences, 19 Yuquan Road, Shijingshan District, Beijing 100049, China

Fujian Normal University, 1 Keji Road, University Town, Fuzhou, Fujian 350117, China

Linsen Li

Shenyang Medical College, 146 North Huanghe Main Street, Shenyang, Liaoning 110034, China

Shanyong Zhou, Joy H. Huang, Jincan Chen, Ping Hu

Chinese Academy of Sciences, Fujian Institute of Research on the Structure of Matter, State Key Laboratory of Structural Chemistry, 155 West Yangqiao Road, Fuzhou, Fujian 350002, China

J. Biomed. Opt. 21(1), 018001 (Jan 07, 2016). doi:10.1117/1.JBO.21.1.018001
History: Received September 16, 2015; Accepted December 4, 2015
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Abstract.  Photodynamic antimicrobial chemotherapy (PACT) is an effective method for killing bacterial cells in view of the increasing problem of multiantibiotic resistance. We herein reported the PACT effect on bacteria involved in skin infections using a zinc phthalocyanine derivative, pentalysine β-carbonylphthalocyanine zinc (ZnPc-(Lys)5). Compared with its anionic ZnPc counterpart, ZnPc-(Lys)5 showed an enhanced antibacterial efficacy in vitro and in an animal model of localized infection. Meanwhile, ZnPc-(Lys)5 was observed to significantly reduce the wound skin blood flow during wound healing, indicating an anti-inflammation activity. This study provides new insight on the mechanisms of PACT in bacterial skin infection.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Zhuo Chen ; Yaxin Zhang ; Dong Wang ; Linsen Li ; Shanyong Zhou, et al.
"Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection", J. Biomed. Opt. 21(1), 018001 (Jan 07, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.1.018001


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