Research Papers: Imaging

Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study

[+] Author Affiliations
Nicusor Iftimia, Ernest W. Chang, Gopi Maguluri

Physical Sciences, Inc., 20 New England Business Center Drive, Andover, Massachusetts 01810, United States

Gary Peterson, Milind Rajadhyaksha

Memorial Sloan-Kettering Cancer Center, Dermatology Service, 16 East 60th Street, New York, New York 10022, United States

William Fox

Caliber I.D., 2320 Brighton Henrietta Town Line Road, Rochester, New York 14623-2708, United States

J. Biomed. Opt. 21(1), 016006 (Jan 18, 2016). doi:10.1117/1.JBO.21.1.016006
History: Received September 7, 2015; Accepted December 14, 2015
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Abstract.  We present a combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) approach, integrated within a single optical layout, for diagnosis of basal cell carcinomas (BCCs) and delineation of margins. While RCM imaging detects BCC presence (diagnoses) and its lateral spreading (margins) with measured resolution of 1  μm, OCT imaging delineates BCC depth spreading (margins) with resolution of 7  μm. When delineating margins in 20 specimens of superficial and nodular BCCs, depth could be reliably determined down to 600  μm, and agreement with histology was within about ±50  μm.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Nicusor Iftimia ; Gary Peterson ; Ernest W. Chang ; Gopi Maguluri ; William Fox, et al.
"Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study", J. Biomed. Opt. 21(1), 016006 (Jan 18, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.1.016006


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