Research Papers: Imaging

Experimental validation of a high-resolution diffuse optical imaging modality: photomagnetic imaging

[+] Author Affiliations
Farouk Nouizi, Alex Luk, Gultekin Gulsen

University of California, Tu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, 164 Irvine Hall, Irvine, California, United States

Dave Thayer

University of California, Tu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, 164 Irvine Hall, Irvine, California, United States

Washington University in St. Louis, Mallinckrodt Institute of Radiology, 510 South Kingshighway Boulevard, St. Louis, Missouri 63110, United States

Yuting Lin

University of California, Tu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, 164 Irvine Hall, Irvine, California, United States

Massachusetts General Hospital and Harvard Medical School, Department of Radiation Oncology, 55 Fruit Street, Boston, Massachusetts 02144, United States

Seunghoon Ha

University of California, Tu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, 164 Irvine Hall, Irvine, California, United States

Philips Healthcare, N27 West 23676 Paul Road, Pewaukee, Wisconsin 53072, United States

J. Biomed. Opt. 21(1), 016009 (Jan 20, 2016). doi:10.1117/1.JBO.21.1.016009
History: Received July 24, 2015; Accepted December 11, 2015
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Abstract.  We present experimental results that validate our imaging technique termed photomagnetic imaging (PMI). PMI illuminates the medium under investigation with a near-infrared light and measures the induced temperature increase using magnetic resonance imaging. A multiphysics solver combining light and heat propagation is used to model spatiotemporal distribution of temperature increase. Furthermore, a dedicated PMI reconstruction algorithm has been developed to reveal high-resolution optical absorption maps from temperature measurements. Being able to perform measurements at any point within the medium, PMI overcomes the limitations of conventional diffuse optical imaging. We present experimental results obtained on agarose phantoms mimicking biological tissue with inclusions having either different sizes or absorption contrasts, located at various depths. The reconstructed images show that PMI can successfully resolve these inclusions with high resolution and recover their absorption coefficient with high-quantitative accuracy. Even a 1-mm inclusion located 6-mm deep is recovered successfully and its absorption coefficient is underestimated by only 32%. The improved PMI system presented here successfully operates under the maximum skin exposure limits defined by the American National Standards Institute, which opens up the exciting possibility of its future clinical use for diagnostic purposes.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Farouk Nouizi ; Alex Luk ; Dave Thayer ; Yuting Lin ; Seunghoon Ha, et al.
"Experimental validation of a high-resolution diffuse optical imaging modality: photomagnetic imaging", J. Biomed. Opt. 21(1), 016009 (Jan 20, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.1.016009


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