Erbium:yttrium aluminum garnet laser cleaning is a promising technique in endodontic treatment. In our in vitro study, we measured the vapor-bubble dynamics in the root canal by using shadow photography. The canal model was made of a plastic cutout placed between two transparent glass plates. An artificial smear layer was applied to the glass to study cleaning efficiency. In our results, no shock waves have been observed, since the pulp-chamber dimensions have been in the same range as the maximum diameter of the vapor bubble. This leads to the conclusion that shock waves are not the main cleaning mechanism within our model. However, the cleaning effects are also visible in the regions significantly below the bubble. Therefore, it can be concluded that fluid flow induced by the bubble’s oscillations contributes significantly to the canal cleaning. We also proposed a simple theoretical model for cleaning efficiency and used it to evaluate the measured data.