Research Papers: Sensing

Dynamic light scattering by flowing Brownian particles measured with optical coherence tomography: impact of the optical system

[+] Author Affiliations
Ivan Popov

University of Toronto, Department of Medical Biophysics, 101 College Street, Toronto, Ontario, Canada M5G 1L7

Alex Vitkin

University of Toronto, Department of Medical Biophysics, 101 College Street, Toronto, Ontario, Canada M5G 1L7

University of Toronto, Department of Radiation Oncology, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9

University Health Network, Ontario Cancer Institute, Division of Biophysics and Bioimaging, 101 College Street, Toronto, Ontario, Canada M5G 1L7

J. Biomed. Opt. 21(1), 017002 (Jan 21, 2016). doi:10.1117/1.JBO.21.1.017002
History: Received October 8, 2015; Accepted December 10, 2015
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Abstract.  The study of flowing Brownian particles finds numerous biomedical applications, ranging from blood flow analysis to diffusion research. A mathematical model for the correlation function of laser radiation scattered by flowing Brownian particles measured with fiber-based optical coherence tomography (OCT), which accounts for the effects of sample arm optics, is presented. It is shown that the parameters of an OCT optical system of any complexity can be taken into account by using the ABCD ray tracing matrix approach. Specifically, the impact of any optical system can be characterized by the changes in the effective beam radius, which replaces the Gaussian beam radius in the existing mathematical models of scattered radiation. It is shown that the validity of the developed ABCD matrix formalism is governed by the condition that the source coherence length is much smaller than the Rayleigh range in the sample. The predictions of the developed model are compared with previously published theories and with experimental data and agree well with the latter.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Ivan Popov and Alex Vitkin
"Dynamic light scattering by flowing Brownian particles measured with optical coherence tomography: impact of the optical system", J. Biomed. Opt. 21(1), 017002 (Jan 21, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.1.017002


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