Research Papers: Therapeutic

Photothermal enhancement of chemotherapy mediated by gold-silica nanoshell-loaded macrophages: in vitro squamous cell carcinoma study

[+] Author Affiliations
Steen J. Madsen, En-Chung Shih

University of Nevada, Department of Health Physics and Diagnostic Sciences, P.O. Box 453037, 4505 South Maryland Parkway, Las Vegas, Nevada 89154, United States

Qian Peng

Oslo University Hospital, Department of Pathology, Montebello, N-03 10, Oslo, Norway

Catherine Christie, Tatiana Krasieva

University of California, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612, United States

Henry Hirschberg

University of Nevada, Department of Health Physics and Diagnostic Sciences, P.O. Box 453037, 4505 South Maryland Parkway, Las Vegas, Nevada 89154, United States

University of California, Beckman Laser Institute, 1002 Health Sciences Road East, Irvine, California 92612, United States

J. Biomed. Opt. 21(1), 018004 (Jan 25, 2016). doi:10.1117/1.JBO.21.1.018004
History: Received July 23, 2015; Accepted December 15, 2015
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Abstract.  Moderate hyperthermia (MHT) has been shown to enhance the effects of chemotherapeutic agents in a wide variety of cancers. The purpose of this study was to investigate the combined effects of commonly used chemotherapeutic agents with MHT induced by near-infrared (NIR) activation of gold nanoshell (AuNS)-loaded macrophages (Ma). AuNS-loaded murine Ma combined with human FaDu squamous cells, in hybrid monolayers, were subjected to three cytotoxic drugs (doxorubicin, bleomycin, cisplatin) with or without NIR laser irradiation. For all three drugs, efficacy was increased by NIR activation of AuNS-loaded Ma. The results of this in vitro study provide proof-of-concept for the use of AuNS-loaded Ma for photothermal enhancement of the effects of chemotherapy on squamous cell carcinoma.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Steen J. Madsen ; En-Chung Shih ; Qian Peng ; Catherine Christie ; Tatiana Krasieva, et al.
"Photothermal enhancement of chemotherapy mediated by gold-silica nanoshell-loaded macrophages: in vitro squamous cell carcinoma study", J. Biomed. Opt. 21(1), 018004 (Jan 25, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.1.018004


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