Research Papers: General

Terahertz spectroscopy of brain tissue from a mouse model of Alzheimer’s disease

[+] Author Affiliations
Lingyan Shi, Adrián Rodríguez-Contreras

The City College of New York, Institute for Ultrafast Spectroscopy and Lasers, Department of Physics, 160 Convent Avenue, New York, New York 10031, United States

The City College of New York, Department of Biology, 160 Convent Avenue, New York, New York 10031, United States

Pavel Shumyatsky, Robert Alfano

The City College of New York, Institute for Ultrafast Spectroscopy and Lasers, Department of Physics, 160 Convent Avenue, New York, New York 10031, United States

J. Biomed. Opt. 21(1), 015014 (Jan 27, 2016). doi:10.1117/1.JBO.21.1.015014
History: Received August 15, 2015; Accepted January 4, 2016
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Abstract.  The terahertz (THz) absorption and index of refraction of brain tissues from a mouse model of Alzheimer’s disease (AD) and a control wild-type (normal) mouse were compared using THz time-domain spectroscopy (THz-TDS). Three dominating absorption peaks associated to torsional–vibrational modes were observed in AD tissue, at about 1.44, 1.8, and 2.114 THz, closer to the peaks of free tryptophan molecules than in normal tissue. A possible reason is that there is more free tryptophan in AD brain tissue, while in normal brain tissue more tryptophan is attached to other molecules. Our study suggests that THz-absorption modes may be used as an AD biomarker fingerprint in brain, and that THz-TDS is a promising technique for early diagnosis of AD.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Lingyan Shi ; Pavel Shumyatsky ; Adrián Rodríguez-Contreras and Robert Alfano
"Terahertz spectroscopy of brain tissue from a mouse model of Alzheimer’s disease", J. Biomed. Opt. 21(1), 015014 (Jan 27, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.1.015014


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