Research Papers: General

Disposable sheath that facilitates endoscopic Raman spectroscopy

[+] Author Affiliations
Wenbo Wang

BC Cancer Agency Research Centre, Imaging Unit-Integrative Oncology Department, 675 West 10th Avenue, Vancouver, British Columbia, V5Z 1L3, Canada

University of British Columbia, Faculty of Applied Science, Department of Biomedical Engineering, KAIS 5500, 2332 Main Mall, Vancouver, British Columbia, V6T1Z4, Canada

Michael Short, Haishan Zeng

BC Cancer Agency Research Centre, Imaging Unit-Integrative Oncology Department, 675 West 10th Avenue, Vancouver, British Columbia, V5Z 1L3, Canada

Isabella T. Tai

BC Cancer Agency, Michael Smith Genome Sciences Centre, 675 West 10th Avenue, Vancouver, British Columbia, V5Z 1L3, Canada

University of British Columbia, Faculty of Medicine, Division of Gastroenterology, 2775 Laurel Street, Vancouver, British Columbia, V5Z 1M9, Canada

J. Biomed. Opt. 21(2), 025001 (Feb 01, 2016). doi:10.1117/1.JBO.21.2.025001
History: Received October 8, 2015; Accepted December 22, 2015
Text Size: A A A

Abstract.  In vivo endoscopic Raman spectroscopy of human tissue using a fiber optic probe has been previously demonstrated. However, there remain several technical challenges, such as a robust control over the laser radiation dose and measurement repeatability during endoscopy. A decrease in the signal to noise was also observed due to aging of Raman probe after repeated cycles of harsh reprocessing procedures. To address these issues, we designed and tested a disposable, biocompatible, and sterile sheath for use with a fiber optic endoscopic Raman probe. The sheath effectively controls contamination of Raman probes between procedures, greatly reduces turnaround time, and slows down the aging of the Raman probes. A small optical window fitted at the sheath cap maintained the measurement distance between Raman probe end and tissue surface. To ensure that the sheath caused a minimal amount of fluorescence and Raman interference, the optical properties of materials for the sheath, optical window, and bonding agent were studied. The easy-to-use sheath can be manufactured at a moderate cost. The sheath strictly enforced a maximum permissible exposure standard of the tissue by the laser and reduced the spectral variability by 1.5 to 8.5 times within the spectral measurement range.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Wenbo Wang ; Michael Short ; Isabella T. Tai and Haishan Zeng
"Disposable sheath that facilitates endoscopic Raman spectroscopy", J. Biomed. Opt. 21(2), 025001 (Feb 01, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.2.025001


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.