Research Papers: Imaging

Retinal optical coherence tomography at 1  μm with dynamic focus control and axial motion tracking

[+] Author Affiliations
Michelle Cua, Sujin Lee, Dongkai Miao, Myeong Jin Ju, Yifan Jian, Marinko V. Sarunic

Simon Fraser University, Department of Engineering Science, 8888 University Drive, Burnaby, British Columbia V5A1S6, Canada

Paul J. Mackenzie

University of British Columbia, Department of Ophthalmology and Visual Science, Eye Care Center, 2550 Willow Street, Vancouver, British Columbia V5Z 3N9, Canada

J. Biomed. Opt. 21(2), 026007 (Feb 15, 2016). doi:10.1117/1.JBO.21.2.026007
History: Received October 15, 2015; Accepted January 19, 2016
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Abstract.  High-resolution optical coherence tomography (OCT) retinal imaging is important to noninvasively visualize the various retinal structures to aid in better understanding of the pathogenesis of vision-robbing diseases. However, conventional OCT systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking OCT system with automatic focus optimization for high-resolution, extended-focal-range clinical retinal imaging by incorporating a variable-focus liquid lens into the sample arm optics. Retinal layer tracking and selection was performed using a graphics processing unit accelerated processing platform for focus optimization, providing real-time layer-specific en face visualization. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the retina and optic nerve head, from which we extracted clinically relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Michelle Cua ; Sujin Lee ; Dongkai Miao ; Myeong Jin Ju ; Paul J. Mackenzie, et al.
"Retinal optical coherence tomography at 1  μm with dynamic focus control and axial motion tracking", J. Biomed. Opt. 21(2), 026007 (Feb 15, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.2.026007


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