Research Papers: Sensing

Simultaneous blood flow and blood oxygenation measurements using a combination of diffuse speckle contrast analysis and near-infrared spectroscopy

[+] Author Affiliations
Myeongsu Seong

Gwangju Institute of Science and Technology, Department of Medical System Engineering, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea

Zephaniah Phillips, V, Phuong Minh Mai

Gwangju Institute of Science and Technology, School of Information and Communications, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea

Chaebeom Yeo, Cheol Song

Daegu Gyeongbuk Institute of Science and Technology, Department of Robotic Engineering, 333 Techno Jungang-Daero, Hyeongpung-myeon, Dalseong-gun, Daegu 42988, Republic of Korea

Kijoon Lee

Daegu Gyeongbuk Institute of Science and Technology, School of Basic Sciences, 333 Techno Jungang-Daero, Hyeongpung-myeon, Dalseong-gun, Daegu 42988, Republic of Korea

Jae Gwan Kim

Gwangju Institute of Science and Technology, Department of Medical System Engineering, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea

Gwangju Institute of Science and Technology, School of Information and Communications, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea

J. Biomed. Opt. 21(2), 027001 (Feb 17, 2016). doi:10.1117/1.JBO.21.2.027001
History: Received October 14, 2015; Accepted January 21, 2016
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Abstract.  A combined diffuse speckle contrast analysis (DSCA)–near-infrared spectroscopy (NIRS) system is proposed to simultaneously measure qualitative blood flow and blood oxygenation changes in human tissue. The system employs an optical switch to alternate two laser sources at two different wavelengths and a CCD camera to capture the speckle image. Therefore, an optical density can be measured from two wavelengths for NIRS measurements and a speckle contrast can be calculated for DSCA measurements. In order to validate the system, a flow phantom test and an arm occlusion protocol for arterial and venous occlusion were performed. Shorter exposure times (<1  ms) show a higher drop (between 50% and 66%) and recovery of 1/KS2 values after occlusion (approximately 150%), but longer exposure time (3 ms) shows more consistent hemodynamic changes. For four subjects, the 1/KS2 values dropped to an average of 82.1±4.0% during the occlusion period and the average recovery of 1/KS2 values after occlusion was 109.1±0.8%. There was also an approximately equivalent amplitude change in oxyhemoglobin (OHb) and deoxyhemoglobin (RHb) during arterial occlusion (maxRHb=0.0085±0.0024  mM/DPF, minOHb=0.0057±0.0044  mM/DPF). The sensitivity of the system makes it a suitable modality to observe qualitative hemodynamic trends during induced physiological changes.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Myeongsu Seong ; Zephaniah Phillips, V ; Phuong Minh Mai ; Chaebeom Yeo ; Cheol Song, et al.
"Simultaneous blood flow and blood oxygenation measurements using a combination of diffuse speckle contrast analysis and near-infrared spectroscopy", J. Biomed. Opt. 21(2), 027001 (Feb 17, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.2.027001


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