Research Papers: Imaging

Laser speckle imaging based on photothermally driven convection

[+] Author Affiliations
Caitlin Regan

University of California–Irvine, Department of Biomedical Engineering, 3120 Natural Sciences II, Irvine, California 92697, United States

Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612, United States

Bernard Choi

University of California–Irvine, Department of Biomedical Engineering, 3120 Natural Sciences II, Irvine, California 92697, United States

Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612, United States

University of California–Irvine, Department of Surgery, 333 City Boulevard West, Suite 1600, Orange, California 92868, United States

Edwards Lifesciences Center for Advanced Cardiovascular Technology, 2400 Engineering Hall, Irvine, California 92697, United States

CHOC Children’s Hospital, 1201 West La Veta Avenue, Orange, California 92868, United States

J. Biomed. Opt. 21(2), 026011 (Feb 26, 2016). doi:10.1117/1.JBO.21.2.026011
History: Received November 17, 2015; Accepted January 25, 2016
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Abstract.  Laser speckle imaging (LSI) is an interferometric technique that provides information about the relative speed of moving scatterers in a sample. Photothermal LSI overcomes limitations in depth resolution faced by conventional LSI by incorporating an excitation pulse to target absorption by hemoglobin within the vascular network. Here we present results from experiments designed to determine the mechanism by which photothermal LSI decreases speckle contrast. We measured the impact of mechanical properties on speckle contrast, as well as the spatiotemporal temperature dynamics and bulk convective motion occurring during photothermal LSI. Our collective data strongly support the hypothesis that photothermal LSI achieves a transient reduction in speckle contrast due to bulk motion associated with thermally driven convection. The ability of photothermal LSI to image structures below a scattering medium may have important preclinical and clinical applications.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Caitlin Regan and Bernard Choi
"Laser speckle imaging based on photothermally driven convection", J. Biomed. Opt. 21(2), 026011 (Feb 26, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.2.026011


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