Special Section on Polarized Light for Biomedical Applications

Use of combined polarization-sensitive optical coherence tomography and Mueller matrix imaging for the polarimetric characterization of excised biological tissue

[+] Author Affiliations
Joseph Chue-Sang, Yuqiang Bai, Susan Stoff, David Straton, Sharan Ramaswamy

Florida International University, Department of Biomedical Engineering, 10555 West Flagler Street, EC 2600, Miami, Florida 33174, United States

Jessica C. Ramella-Roman

Florida International University, Department of Biomedical Engineering, 10555 West Flagler Street, EC 2600, Miami, Florida 33174, United States

Florida International University, Herbert Wertheim College of Medicine, 11200 SW 8th Street, AHC2, Miami, Florida 33199, United States

J. Biomed. Opt. 21(7), 071109 (Mar 01, 2016). doi:10.1117/1.JBO.21.7.071109
History: Received October 19, 2015; Accepted January 28, 2016
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Abstract.  Mueller matrix polarimetry and polarization-sensitive optical coherence tomography (PS-OCT) are two emerging techniques utilized in the assessment of tissue anisotropy. While PS-OCT can provide cross-sectional images of local tissue birefringence through its polarimetric sensitivity, Mueller matrix polarimetry can be used to measure bulk polarimetric properties such as depolarization, diattenuation, and retardance. To this day true quantification of PS-OCT data can be elusive, partly due to the reliance on inverse models for the characterization of tissue birefringence and the influence of instrumentation noise. Similarly for Mueller matrix polarimetry, calculation of retardance or depolarization may be influenced by tissue heterogeneities that could be monitored with PS-OCT. Here, we propose an instrument that combines Mueller matrix polarimetry and PS-OCT. Through the co-registration of the two systems, we aim at achieving a better understanding of both modalities.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Joseph Chue-Sang ; Yuqiang Bai ; Susan Stoff ; David Straton ; Sharan Ramaswamy, et al.
"Use of combined polarization-sensitive optical coherence tomography and Mueller matrix imaging for the polarimetric characterization of excised biological tissue", J. Biomed. Opt. 21(7), 071109 (Mar 01, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.7.071109


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