Currently, the main diagnostic method for MIH is clinical visual examination of the teeth. This can be performed with the aid of indices used to describe enamel defects, such as the modified developmental defects of enamel index (mDDE index)11 or the European Association of Pediatric Dentistry (EAPD) MIH index, the latter requiring the examination of 12 permanent teeth (8 permanent incisors and 4 FPMs) at the age of eight.4 Diagnosis at an early stage is key in the management of MIH teeth, in order to reinforce oral hygiene, to maximize opportunities for teeth remineralization, and to reduce hypersensitivity. The available treatment options for MIH teeth are complex, ranging from prevention and restoration to extraction, depending on the patient’s dental age, the severity of the condition, the child/parent’s expectations, and background.12 One major challenge is the assessment of the depth of the involved tissue, which has major impacts upon the specific design of the treatment plan to mask, remove, or cover the affected regions. Therefore, the determination of the extent of an MIH lesion into the enamel depths is crucial to determine the prognosis and treatment plan for affected teeth. However, this can be difficult to evaluate accurately solely from clinical examination, and as the lesions are superimposed on the bulk of the tooth structure. Similarly, such imaging modalities offer poor spatial resolution. Ultrahigh resolution clinical three-dimensional (3-D) techniques, such as cone beam computed tomography, necessitates significant radiological doses and are probably not justified in these scenarios, when no other radiological alternatives are possible.