Research Papers: Imaging

Delay-multiply-and-sum-based synthetic aperture focusing in photoacoustic microscopy

[+] Author Affiliations
Jongin Park, Seungwan Jeon, Jin S. Lee, Chulhong Kim

Pohang University of Science and Technology, Departments of Electrical Engineering and Creative IT Engineering, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 790-784, Republic of Korea

Jing Meng

Qufu Normal University, School of Information Science and Technology, 80 Yantai Road North, Rizhao 276826, China

Liang Song

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Institute of Biomedical and Health, 1068 Xueyuan Avenue, University Town of Shenzhen, Shenzhen 518055, China

J. Biomed. Opt. 21(3), 036010 (Mar 28, 2016). doi:10.1117/1.JBO.21.3.036010
History: Received November 20, 2015; Accepted March 7, 2016
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Abstract.  We propose an improved version of a synthetic aperture focusing technique (SAFT) based on a delay-multiply-and-sum algorithm for acoustic-resolution photoacoustic microscopy (AR-PAM). In this method, the photoacoustic (PA) signals from multiple scan-lines are combinatorially coupled, multiplied, and then summed. This process can be considered a correlation operation of the PA signals in each scan-line, so the spatial coherent information between the PA signals can be efficiently extracted. By applying this method in conventional AR-PAM, lateral resolution and signal-to-noise ratio in out-of-focus regions are much improved compared with those estimated from the previously developed SAFT, respectively, thereby achieving the extension of the imaging focal region. Our phantom and in vivo imaging experiments prove the validity of our proposed method.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Jongin Park ; Seungwan Jeon ; Jing Meng ; Liang Song ; Jin S. Lee, et al.
"Delay-multiply-and-sum-based synthetic aperture focusing in photoacoustic microscopy", J. Biomed. Opt. 21(3), 036010 (Mar 28, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.3.036010


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