Special Section on Clinical Near-Infrared Spectroscopy and Imaging

Assessment of human brown adipose tissue density during daily ingestion of thermogenic capsinoids using near-infrared time-resolved spectroscopy

[+] Author Affiliations
Shinsuke Nirengi

Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Division of Preventive Medicine, 1-1 Mukaihata-cho, Fukakusa, Kyoto, 612-8555, Japan

Ritsumeikan University, Graduate School of Sport and Health Science, 1-1-1 Nojihigashi, Kusatsu, 525-8577, Japan

Toshiyuki Homma

Daito Bunka University, Faculty of Sports and Health Science, 1-9-1 Takashimadaira, Itabashi-ku, Tokyo 175-8571, Japan

Naohiko Inoue

Ajinomoto Co., Inc., Institute of Food Science & Technologies, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki 210-8681, Japan

Hitoshi Sato

Ajinomoto Co., Inc., Health & Wellness Business Dept., 15-1, Kyobashi 1-chome, Chuo-ku, Tokyo 104-8315, Japan

Takeshi Yoneshiro

Hokkaido University, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Kita 8, Nishi 5, Kita-ku, Sapporo 060-0808, Japan

Mami Matsushita

Tenshi College, Department of Nutrition, 1-30, Kita 13, Higashi 3, Higashi-ku, Sapporo 065-0013, Japan

Toshimitsu Kameya, Hiroki Sugie

LSI Sapporo Clinic, 2-50, Kita 13, Higashi 1, Higashi-ku, Sapporo 065-0013, Japan

Kokoro Tsuzaki, Naoki Sakane

Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Division of Preventive Medicine, 1-1 Mukaihata-cho, Fukakusa, Kyoto, 612-8555, Japan

Masayuki Saito

Hokkaido University, Kita 8, Nishi 5, Kita-ku, Sapporo 060-0808, Japan

Yuko Kurosawa, Takafumi Hamaoka

Tokyo Medical University, Department of Sports Medicine for Health Promotion, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan

J. Biomed. Opt. 21(9), 091305 (May 02, 2016). doi:10.1117/1.JBO.21.9.091305
History: Received December 31, 2015; Accepted March 29, 2016
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Abstract.  F18-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) is widely used as a standard method for evaluating human brown adipose tissue (BAT), a recognized therapeutic target of obesity. However, a longitudinal BAT study using FDG-PET/CT is lacking owing to limitations of the method. Near-infrared time-resolved spectroscopy (NIRTRS) is a technique for evaluating human BAT density noninvasively. This study aimed to test whether NIRTRS could detect changes in BAT density during or after long-term intervention. First, using FDG-PET/CT, we confirmed a significant increase (+48.8%, P<0.05) in BAT activity in the supraclavicular region after 6-week treatment with thermogenic capsaicin analogs, capsinoids. Next, 20 volunteers were administered either capsinoids or placebo daily for 8 weeks in a double-blind design, and BAT density was measured using NIRTRS every 2 weeks during the 8-week treatment period and an 8-week period after stopping treatment. Consistent with FDG-PET/CT results, NIRTRS successfully detected an increase in BAT density during the 8-week treatment (+46.4%, P<0.05), and a decrease in the 8-week follow-up period (12.5%, P=0.07), only in the capsinoid-treated, but not the placebo, group. Thus, NIRTRS can be applied for quantitative assessment of BAT in longitudinal intervention studies in humans.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Shinsuke Nirengi ; Toshiyuki Homma ; Naohiko Inoue ; Hitoshi Sato ; Takeshi Yoneshiro, et al.
"Assessment of human brown adipose tissue density during daily ingestion of thermogenic capsinoids using near-infrared time-resolved spectroscopy", J. Biomed. Opt. 21(9), 091305 (May 02, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.9.091305


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