JBO Letters

Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery

[+] Author Affiliations
Antonello Enrico Spinelli

San Raffaele Scientific Institute, Experimental Imaging Centre, Via Olgettina N. 60, Milan 20182 Italy

Marco P. Schiariti

Neurological Institute C. Besta, Neurosurgery unit 2, Via Celoria 11, Milano 20133, Italy

Chiara M. Grana

European Institute of Oncology, Nuclear Medicine Department, Via Ripamonti 435, Milan 20141, Italy

Mahila Ferrari, Marta Cremonesi

European Institute of Oncology, Medical Physics Unit, Via Ripamonti 435, Milan 20141, Italy

Federico Boschi

University of Verona, Department of Computer Science, Strada Le Grazie 15, Verona 37134, Italy

J. Biomed. Opt. 21(5), 050502 (May 09, 2016). doi:10.1117/1.JBO.21.5.050502
History: Received March 29, 2016; Accepted April 18, 2016
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Abstract.  We presented the first example of Cerenkov luminescence imaging (CLI) and radioluminescence imaging (RLI) of human tumor specimens. A patient with a brain meningioma localized in the left parietal region was injected with 166 MBq of Y90-DOTATOC the day before neurosurgery. The specimens of the tumor removed during surgery were imaged using both CLI and RLI using an optical imager prototype developed in our laboratory. The system is based on a cooled electron multiplied charge coupled device coupled with an f/0.95 17-mm C-mount lens. We showed for the first time the possibility of obtaining CLI and RLI images of fresh human brain tumor specimens removed during neurosurgery.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Antonello Enrico Spinelli ; Marco P. Schiariti ; Chiara M. Grana ; Mahila Ferrari ; Marta Cremonesi, et al.
"Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery", J. Biomed. Opt. 21(5), 050502 (May 09, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.5.050502


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