Special Section on Tissue and Blood Optical Clearing for Biomedical Applications

Study of optical clearing in polarization measurements by Monte Carlo simulations with anisotropic tissue-mimicking models

[+] Author Affiliations
Dongsheng Chen, Yunfei Wang, Hui Ma

Tsinghua University, Graduate School at Shenzhen, Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, 2279 Lishui Road, Shenzhen 518055, China

Tsinghua University, Department of Physics, 30 Shuangqing Road, Beijing 100084, China

Nan Zeng

Tsinghua University, Graduate School at Shenzhen, Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, 2279 Lishui Road, Shenzhen 518055, China

Honghui He

Tsinghua University, Department of Physics, 30 Shuangqing Road, Beijing 100084, China

Valery V. Tuchin

Saratov State University, Research-Educational Institute of Optics and Biophotonics, 83 Astrakhanskaya Street, Saratov 410012, Russia

Tomsk State University, Laboratory of Biophotonics, 36 Lenin Avenue, Tomsk 634050, Russia

Institute of Precision Mechanics and Control of RAS, 24 Rabochaya Street, Saratov 410028, Russia

J. Biomed. Opt. 21(8), 081209 (May 31, 2016). doi:10.1117/1.JBO.21.8.081209
History: Received December 31, 2015; Accepted May 2, 2016
Text Size: A A A

Abstract.  We conducted Monte Carlo simulations based on anisotropic sclera-mimicking models to examine the polarization features in Mueller matrix polar decomposition (MMPD) parameters during the refractive index matching process, which is one of the major mechanisms of optical clearing. In a preliminary attempt, by changing the parameters of the models, wavelengths, and detection geometries, we demonstrate how the depolarization coefficient and retardance vary during the refractive index matching process and explain the polarization features using the average value and standard deviation of scattering numbers of the detected photons. We also study the depth-resolved polarization features during the gradual progression of the refractive index matching process. The results above indicate that the refractive index matching process increases the depth of polarization measurements and may lead to higher contrast between tissues of different anisotropies in deeper layers. MMPD-derived polarization parameters can characterize the refractive index matching process qualitatively.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Dongsheng Chen ; Nan Zeng ; Yunfei Wang ; Honghui He ; Valery V. Tuchin, et al.
"Study of optical clearing in polarization measurements by Monte Carlo simulations with anisotropic tissue-mimicking models", J. Biomed. Opt. 21(8), 081209 (May 31, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.8.081209


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.