Research Papers: General

ACA-Pro: calibration protocol for quantitative diffuse reflectance spectroscopy. Validation on contact and noncontact probe- and CCD-based systems

[+] Author Affiliations
Veronica Sorgato, Michel Berger, Charlotte Emain, Jean-Marc Dinten, Anne Planat-Chrétien

CEA-LETI, Minatec Campus, 17 Rue des Martyrs, F38054 Grenoble, Cedex 9, France

Christine Vever-Bizet, Geneviève Bourg-Heckly

UPMC University Paris 06, UMR8237, Laboratoire Jean Perrin, F-75005, Paris, France

CNRS, UMR8237, Laboratoire Jean Perrin, F-75005, Paris, France

J. Biomed. Opt. 21(6), 065003 (Jun 09, 2016). doi:10.1117/1.JBO.21.6.065003
History: Received January 18, 2016; Accepted May 11, 2016
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Abstract.  We have developed an adaptive calibration algorithm and protocol (ACA-Pro) that corrects from the instrumental response of various spatially resolved diffuse reflectance spectroscopy (DRSsr) systems to enable the quantification of absorption and scattering properties based on a Monte Carlo-based look-up-table approach. The protocol involves the use of a calibration reference base built with measurements of a range of different diffusive intralipid phantoms. Moreover, an advanced strategy was established to take into account the experimental variations with an additional measurement of a common solid material, allowing the use of a single calibration reference base for all experiments. The ACA-Pro is validated in contact and noncontact probe-based DRSsr systems. Furthermore, the first results of a setup replacing the probe with a CCD detector are shown to confirm the robustness of the approach.

© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Veronica Sorgato ; Michel Berger ; Charlotte Emain ; Christine Vever-Bizet ; Jean-Marc Dinten, et al.
"ACA-Pro: calibration protocol for quantitative diffuse reflectance spectroscopy. Validation on contact and noncontact probe- and CCD-based systems", J. Biomed. Opt. 21(6), 065003 (Jun 09, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.6.065003


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