Research Papers: Imaging

Dual-band optical coherence tomography using a single supercontinuum laser source

[+] Author Affiliations
Siyu Chen, Xiao Shu

Northwestern University, Department of Biomedical Engineering, 2145 Sheridan Road, Evanston, Illinois 60208, United States

Ji Yi

Northwestern University, Department of Biomedical Engineering, 2145 Sheridan Road, Evanston, Illinois 60208, United States

Boston University, Department of Medicine, 650 Albany Street, Boston, Massachusetts 02118, United States

Amani Fawzi

Northwestern University, Department of Ophthalmology, 300 East Superior Street, Chicago, Illinois 60611, United States

Hao F. Zhang

Northwestern University, Department of Biomedical Engineering, 2145 Sheridan Road, Evanston, Illinois 60208, United States

Northwestern University, Department of Ophthalmology, 300 East Superior Street, Chicago, Illinois 60611, United States

J. Biomed. Opt. 21(6), 066013 (Jun 15, 2016). doi:10.1117/1.JBO.21.6.066013
History: Received February 15, 2016; Accepted May 20, 2016
Text Size: A A A

Abstract.  We developed a simultaneous visible-light (Vis) and near-infrared (NIR) dual-band optical coherence tomography (OCT) system using a single supercontinuum laser source. The goal was to benchmark our newly developed Vis-OCT against the well-developed NIR-OCT. The Vis-OCT subsystem operated at 91 nm full-width-at-half-maximum (FWHM) bandwidth centered at 566 nm; the NIR-OCT subsystem operated at 93 nm FWHM bandwidth centered at 841 nm. The axial resolutions were 1.8 and 4.4  μm in air for the Vis- and NIR-OCT subsystems, respectively. We compared the respective performances, including anatomical imaging, angiography, absolute retinal blood flow measurements, and spectroscopic analysis for retinal blood oxygen saturation (sO2), between the two subsystems in rodents in vivo. While demonstrating minor discrepancies related to operation wavelengths, both subsystems showed comparable performances in the first three tests. However, we were only able to retrieve sO2 using the Vis-OCT subsystem.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Topics

Near infrared

Citation

Siyu Chen ; Xiao Shu ; Ji Yi ; Amani Fawzi and Hao F. Zhang
"Dual-band optical coherence tomography using a single supercontinuum laser source", J. Biomed. Opt. 21(6), 066013 (Jun 15, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.6.066013


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.