Special Series on Translational Biophotonics

In vivo imaging of melanoma-implanted magnetic nanoparticles using contrast-enhanced magneto-motive optical Doppler tomography

[+] Author Affiliations
Ruchire Eranga Wijesinghe, Kibeom Park, Mansik Jeon, Jeehyun Kim

Kyungpook National University, School of Electronics Engineering, College of IT Engineering, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea

Dong-Hyeon Kim

3D Convergence Technology Center, 70 Dongnae-ro, Daegu 41061, Republic of Korea

J. Biomed. Opt. 21(6), 064001 (Jun 21, 2016). doi:10.1117/1.JBO.21.6.064001
History: Received January 20, 2016; Accepted June 1, 2016
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Abstract.  We conducted an initial feasibility study using real-time magneto-motive optical Doppler tomography (MM-ODT) with enhanced contrast to investigate the detection of superparamagnetic iron oxide (SPIO) magnetic nanoparticles implanted into in vivo melanoma tissue. The MM-ODT signals were detected owing to the phase shift of the implanted magnetic nanoparticles, which occurred due to the action of an applied magnetic field. An amplifier circuit-based solenoid was utilized for generating high-intensity oscillating magnetic fields. The MM-ODT system was confirmed as an effective in vivo imaging method for detecting melanoma tissue, with the performance comparable to those of conventional optical coherence tomography and optical Doppler tomography methods. Moreover, the optimal values of the SPIO nanoparticles concentration and solenoid voltage for obtaining the uppermost Doppler velocity were derived as well. To improve the signal processing speed for real-time imaging, we adopted multithread programming techniques and optimized the signal path. The results suggest that this imaging modality can be used as a powerful tool to identify the intracellular and extracellular SPIO nanoparticles in melanoma tissues in vivo.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Ruchire Eranga Wijesinghe ; Kibeom Park ; Dong-Hyeon Kim ; Mansik Jeon and Jeehyun Kim
"In vivo imaging of melanoma-implanted magnetic nanoparticles using contrast-enhanced magneto-motive optical Doppler tomography", J. Biomed. Opt. 21(6), 064001 (Jun 21, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.6.064001


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