Research Papers: General

Characterization of lipid-rich plaques using spectroscopic optical coherence tomography

[+] Author Affiliations
Hyeong Soo Nam, Hongki Yoo

Hanyang University, Department of Biomedical Engineering, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea

Joon Woo Song, Jae Joong Lee, Jin Won Kim

Korea University Guro Hospital, Cardiovascular Center, 148 Gurodong-ro, Guro-gu, Seoul 08308 Republic of Korea

Sun-Joo Jang, Wang-Yuhl Oh

Korea Advanced Institute of Science and Technology, Department of Mechanical Engineering, 291 Gwahang-no, Yuseong-gu, Daejeon 34141, Republic of Korea

J. Biomed. Opt. 21(7), 075004 (Jul 08, 2016). doi:10.1117/1.JBO.21.7.075004
History: Received March 24, 2016; Accepted June 22, 2016
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Abstract.  Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Hyeong Soo Nam ; Joon Woo Song ; Sun-Joo Jang ; Jae Joong Lee ; Wang-Yuhl Oh, et al.
"Characterization of lipid-rich plaques using spectroscopic optical coherence tomography", J. Biomed. Opt. 21(7), 075004 (Jul 08, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.7.075004


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