Research Papers: Imaging

Continuous-terahertz-wave molecular imaging system for biomedical applications

[+] Author Affiliations
Rui Zhang

Peking University, College of Engineering, No. 8 YiHeYuan Road, Beijing 100871, China

Liangliang Zhang, Tong Wu, Cunlin Zhang

Capital Normal University, Department of Physics, No. 105 XiSanHuan BeiLu, Beijing 100048, China

Ruixue Wang, Shasha Zuo, Dong Wu

Peking University, Academy for Advanced Interdisciplinary Studies, No. 8 YiHeYuan Road, Beijing 100871, China

Jue Zhang, Jing Fang

Peking University, College of Engineering, No. 8 YiHeYuan Road, Beijing 100871, China

Peking University, Academy for Advanced Interdisciplinary Studies, No. 8 YiHeYuan Road, Beijing 100871, China

J. Biomed. Opt. 21(7), 076006 (Jul 12, 2016). doi:10.1117/1.JBO.21.7.076006
History: Received February 1, 2016; Accepted May 23, 2016
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Abstract.  Molecular imaging techniques are becoming increasingly important in biomedical research and potentially in clinical practice. We present a continuous-terahertz (THz)-wave molecular imaging system for biomedical applications, in which an infrared (IR) laser is integrated into a 0.2-THz reflection-mode continuous-THz-wave imaging system to induce surface plasmon polaritons on the nanoparticles and further improve the intensity of the reflected signal from the water around the nanoparticles. A strong and rapid increment of the reflected THz signal in the nanoparticle solution upon the IR laser irradiation is demonstrated, using either gold or silver nanoparticles. This low-cost, simple, and stable continuous-THz-wave molecular imaging system is suitable for miniaturization and practical imaging applications; in particular, it shows great promise for cancer diagnosis and nanoparticle drug-delivery monitoring.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Rui Zhang ; Liangliang Zhang ; Tong Wu ; Ruixue Wang ; Shasha Zuo, et al.
"Continuous-terahertz-wave molecular imaging system for biomedical applications", J. Biomed. Opt. 21(7), 076006 (Jul 12, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.7.076006


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