JBO Letters

Continuous-wave circular polarization terahertz imaging

[+] Author Affiliations
Jillian P. Martin, Cecil S. Joseph, Robert H. Giles

University of Massachusetts Lowell, Department of Physics and Applied Physics, 136 Olney Science Center, 1 University Avenue, Lowell, Massachusetts 01854, United States

Biomedical Terahertz Technology Center, 175 Cabot Street, Suite 114, Lowell, Massachusetts 01854, United States

J. Biomed. Opt. 21(7), 070502 (Jul 14, 2016). doi:10.1117/1.JBO.21.7.070502
History: Received May 16, 2016; Accepted June 24, 2016
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Abstract.  Biomedical applications of terahertz (THz) radiation are appealing because THz radiation is nonionizing and has the demonstrated ability to detect intrinsic contrasts between cancerous and normal tissue. A linear polarization-sensitive detection technique for tumor margin delineation has already been demonstrated; however, utilization of a circular polarization-sensitive detection technique has yet to be explored at THz frequencies. A reflective, continuous-wave THz imaging system capable of illuminating a target sample at 584 GHz with either linearly or circularly polarized radiation, and capable of collecting both cross- and copolarized signals remitted from the target, is implemented. To demonstrate the system’s utility, a fresh ex vivo human skin tissue specimen containing nonmelanoma skin cancer was imaged. Both polarization-sensitive detection techniques showed contrast between tumor and normal skin tissue, although some differences in images were observed between the two techniques. Our results indicate that further investigation is required to explain the contrast mechanism, as well as to quantify the specificity and sensitivity of the circular polarization-sensitive detection technique.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Jillian P. Martin ; Cecil S. Joseph and Robert H. Giles
"Continuous-wave circular polarization terahertz imaging", J. Biomed. Opt. 21(7), 070502 (Jul 14, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.7.070502


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