Research Papers: Imaging

Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration

[+] Author Affiliations
Nicolai Brill, Mathias Wirtz

Fraunhofer Institute for Production Technology, Steinbachstraße 17, Aachen 52074, Germany

Dorit Merhof

RWTH Aachen University, Institute of Imaging and Computer Vision, Kopernikusstraße 16, Aachen 52074, Germany

Markus Tingart, Holger Jahr

Aachen University Hospital, Department of Orthopaedic Surgery, Pauwelsstraße 30, Aachen 52074, Germany

Daniel Truhn, Sven Nebelung

Aachen University Hospital, Department of Diagnostic and Interventional Radiology, Pauwelsstraße 30, Aachen 52074, Germany

Robert Schmitt

Fraunhofer Institute for Production Technology, Steinbachstraße 17, Aachen 52074, Germany

RWTH Aachen University, Laboratory for Machine Tools and Production Engineering, Manfred-Weck Haus, Steinbachstraße 19, Aachen 52074, Germany

J. Biomed. Opt. 21(7), 076013 (Jul 22, 2016). doi:10.1117/1.JBO.21.7.076013
History: Received April 30, 2016; Accepted July 6, 2016
Text Size: A A A

Abstract.  Polarization-sensitive optical coherence tomography (PS-OCT) is a light-based, high-resolution, real-time, noninvasive, and nondestructive imaging modality yielding quasimicroscopic cross-sectional images of cartilage. As yet, comprehensive parameterization and quantification of birefringence and tissue properties have not been performed on human cartilage. PS-OCT and algorithm-based image analysis were used to objectively grade human cartilage degeneration in terms of surface irregularity, tissue homogeneity, signal attenuation, as well as birefringence coefficient and band width, height, depth, and number. Degeneration-dependent changes were noted for the former three parameters exclusively, thereby questioning the diagnostic value of PS-OCT in the assessment of human cartilage degeneration.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Nicolai Brill ; Mathias Wirtz ; Dorit Merhof ; Markus Tingart ; Holger Jahr, et al.
"Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration", J. Biomed. Opt. 21(7), 076013 (Jul 22, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.7.076013


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.