Research Papers: Imaging

Microvascular contrast enhancement in optical coherence tomography using microbubbles

[+] Author Affiliations
Homa Assadi

Ryerson University, Department of Physics, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada

Valentin Demidov

University of Toronto, Department of Medical Biophysics, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Room 15-701, Toronto, Ontario M5G 1L7, Canada

Raffi Karshafian, Alexandre Douplik

Ryerson University, Department of Physics, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada

St. Michael Hospital, Keenan Research Centre of the LKS Knowledge Institute, 209 Victoria Street, Toronto M5B 1W8, Canada

I. Alex Vitkin

University of Toronto, Department of Medical Biophysics, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Room 15-701, Toronto, Ontario M5G 1L7, Canada

University Health Network, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada

University of Toronto, Department of Radiation Oncology, 150 College Street, FitzGerald Building, Room 106, Toronto, Ontario M5S 3E2, Canada

J. Biomed. Opt. 21(7), 076014 (Jul 28, 2016). doi:10.1117/1.JBO.21.7.076014
History: Received November 6, 2015; Accepted July 11, 2016
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Abstract.  Gas microbubbles (MBs) are investigated as intravascular optical coherence tomography (OCT) contrast agents. Agar + intralipid scattering tissue phantoms with two embedded microtubes were fabricated to model vascular blood flow. One was filled with human blood, and the other with a mixture of human blood + MB. Swept-source structural and speckle variance (sv) OCT images, as well as speckle decorrelation times, were evaluated under both no-flow and varying flow conditions. Faster decorrelation times and higher structural and svOCT image contrasts were detected in the presence of MB in all experiments. The effects were largest in the svOCT imaging mode, and uniformly diminished with increasing flow velocity. These findings suggest the feasibility of utilizing MB for tissue hemodynamic investigations and for microvasculature contrast enhancement in OCT angiography.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Homa Assadi ; Valentin Demidov ; Raffi Karshafian ; Alexandre Douplik and I. Alex Vitkin
"Microvascular contrast enhancement in optical coherence tomography using microbubbles", J. Biomed. Opt. 21(7), 076014 (Jul 28, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.7.076014


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