Research Papers: Imaging

Hybrid multispectral optoacoustic and ultrasound tomography for morphological and physiological brain imaging

[+] Author Affiliations
Ivan Olefir, Saak V. Ovsepian, Vasilis Ntziachristos

Helmholtz Zentrum München, Institute for Biological and Medical Imaging, Ingolstädter Landstraße 1, Neuherberg 85764, Germany

Technische Universität München, School of Bioengineering, Boltzmannstraße 11, Garching 85748, Germany

Elena Merčep

Helmholtz Zentrum München, Institute for Biological and Medical Imaging, Ingolstädter Landstraße 1, Neuherberg 85764, Germany

Technische Universität München, Faculty of Medicine, Ismaninger Straße 22, Munich 81675, Germany

iThera Medical GmbH, Zielstattstrasse 13, Munich 81379, Germany

Neal C. Burton

iThera Medical GmbH, Zielstattstrasse 13, Munich 81379, Germany

J. Biomed. Opt. 21(8), 086005 (Aug 12, 2016). doi:10.1117/1.JBO.21.8.086005
History: Received April 14, 2016; Accepted July 25, 2016
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Abstract.  Expanding usage of small animal models in biomedical research necessitates development of technologies for structural, functional, or molecular imaging that can be readily integrated in the biological laboratory. Herein, we consider dual multispectral optoacoustic (OA) and ultrasound tomography based on curved ultrasound detector arrays and describe the performance achieved for hybrid morphological and physiological brain imaging of mice in vivo. We showcase coregistered hemodynamic parameters resolved by OA tomography under baseline conditions and during alterations of blood oxygen saturation. As an internal reference, we provide imaging of abdominal organs. We illustrate the performance advantages of hybrid curved detector ultrasound and OA tomography and discuss immediate and long-term implications of our findings in the context of animal and human studies.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Ivan Olefir ; Elena Merčep ; Neal C. Burton ; Saak V. Ovsepian and Vasilis Ntziachristos
"Hybrid multispectral optoacoustic and ultrasound tomography for morphological and physiological brain imaging", J. Biomed. Opt. 21(8), 086005 (Aug 12, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.8.086005


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