Research Papers: General

Focusing light through biological tissue and tissue-mimicking phantoms up to 9.6 cm in thickness with digital optical phase conjugation

[+] Author Affiliations
Yuecheng Shen, Yan Liu, Cheng Ma, Lihong V. Wang

Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, One Brookings Drive, St. Louis, Missouri 63130, United States

J. Biomed. Opt. 21(8), 085001 (Aug 12, 2016). doi:10.1117/1.JBO.21.8.085001
History: Received June 2, 2016; Accepted July 25, 2016
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Abstract.  Optical phase conjugation (OPC)-based wavefront shaping techniques focus light through or within scattering media, which is critically important for deep-tissue optical imaging, manipulation, and therapy. However, to date, the sample thickness in OPC experiments has been limited to only a few millimeters. Here, by using a laser with a long coherence length and an optimized digital OPC system that can safely deliver more light power, we focused 532-nm light through tissue-mimicking phantoms up to 9.6 cm thick, as well as through ex vivo chicken breast tissue up to 2.5 cm thick. Our results demonstrate that OPC can be achieved even when photons have experienced on average 1000 scattering events. The demonstrated penetration of nearly 10 cm (100 transport mean free paths) has never been achieved before by any optical focusing technique, and it shows the promise of OPC for deep-tissue noninvasive optical imaging, manipulation, and therapy.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Yuecheng Shen ; Yan Liu ; Cheng Ma and Lihong V. Wang
"Focusing light through biological tissue and tissue-mimicking phantoms up to 9.6 cm in thickness with digital optical phase conjugation", J. Biomed. Opt. 21(8), 085001 (Aug 12, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.8.085001


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